天然气 → 3-(3,4,5-三甲氧基苯基)丙酸

HRID 1387739

反应方程式

HRID 1387739 反应方程式
[C:1](=[O:4])([O-])[O-:2].[K+].[K+].[CH3:7][O:8][C:9]1[CH:10]=[C:11]([C:19](=C)[C:20](O)=O)[CH:12]=[C:13]([O:17][CH3:18])[C:14]=1[O:15][CH3:16].C.[H][H]>[Pd].O>[CH3:18][O:17][C:13]1[CH:12]=[C:11]([CH2:19][CH2:20][C:1]([OH:2])=[O:4])[CH:10]=[C:9]([O:8][CH3:7])[C:14]=1[O:15][CH3:16]

参与物

7

反应物 4

HCID 297天然气HCID 11430碳酸钾HCID 208491922-(3,4,5-Trimethoxyphenyl)prop-2-enoic acidHCID 178418361HCID 178418361，化合物

产物 1

HCID 648603-(3,4,5-三甲氧基苯基)丙酸收率 167.5%

试剂、催化剂与溶剂 2

HCID 23938钯催化剂HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂

实验过程

6.8 g of potassium carbonate were added to a solution of 21.44 g of 3,4,5-trimethoxyphenylpropenoic acid and 45 ml of water and the mixture was hydrogenated for one hour under a pressure of 1200-1300 mbar in the presence of 1.8 g of activated charcoal with 10% of palladium during which 2.1 liters of hydrogen were absorbed. Filtration was carried out, followed by washing with water and acidifying with 50 ml of hydrochloric acid (2N). The product was separated off, washed with water and dried under reduced pressure at ambient temperature to obtain 19.8 g of the expected product melting at 102-103° C.

后处理

  1. customwere absorbed
  2. filtrationFiltration
  3. washby washing with water and acidifying with 50 ml of hydrochloric acid (2N)
  4. customThe product was separated off
  5. washwashed with water
  6. customdried under reduced pressure at ambient temperature

来源与证据

ORD记录
ord-2137703f39224178b661a5a543bc1727
来源数据集
uspto-grants-2001_07
专利号
US06268520B1

关联笔记

加载中…