苯酚 → HCID 85995662，化合物
反应方程式
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:8][C:9]1[CH:16]=[C:15](F)[CH:14]=[C:13]([CH3:18])[C:10]=1[CH:11]=[O:12].C([O-])([O-])=O.[K+].[K+]>CC(N(C)C)=O>[CH3:8][C:9]1[CH:16]=[C:15]([O:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH:14]=[C:13]([CH3:18])[C:10]=1[CH:11]=[O:12]参与物
5
反应条件
- 温度
- 150 °C
实验过程
2.3 g (25 mmol) of phenol and 3.8 g (25 mmol) of 2,6-dimethyl-4-fluorobenzaldehyde were dissolved in 60 ml DMA, combined with 4.8 g (35 mmol) of K2CO3 and stirred at 150° C. for 5 min in a microwave (OEM Discoverer), filtered through basic Alox, washed with DMF and concentrated by rotary evaporation. Taken up in a mixture of acetonitrile/water. The substance crystallised, was filtered off and dried.
后处理
- filtrationfiltered through basic Alox
- washwashed with DMF
- concentrationconcentrated by rotary evaporation
- additionTaken up in a mixture of acetonitrile/water
- customThe substance crystallised
- filtrationwas filtered off
- customdried
来源与证据
- ORD记录
- ord-4fb3bdc711b94d2d8cc7d46d36d91e25
- 来源数据集
- uspto-grants-2014_12
- 专利号
- US08916589B2
反应笔记
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