1-(2-甲氧苯基)哌嗪 → 3-[4-[1-(2-Methoxyphenyl)-4-piperazinyl]butyl]-2-Methyl-4-thiazolidinone

HRID 1491908笔记

反应方程式

HRID 1491908 反应方程式
[CH3:1][CH:2]1[N:6]([CH2:7][CH2:8][CH2:9][CH2:10]Br)[C:5](=[O:12])[CH2:4][S:3]1.[CH3:13][O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1.C([O-])([O-])=O.[K+].[K+].[Na+].[I-]>CC#N>[CH3:13][O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[N:21]1[CH2:26][CH2:25][N:24]([CH2:10][CH2:9][CH2:8][CH2:7][N:6]2[C:5](=[O:12])[CH2:4][S:3][CH:2]2[CH3:1])[CH2:23][CH2:22]1

参与物

6

反应物 4

HCID 13461-(2-甲氧苯基)哌嗪HCID 5238碘化钠HCID 11430碳酸钾HCID 104909933-(4-Bromobutyl)-2-methyl-4-thiazolidinone

产物 1

HCID 156623253-[4-[1-(2-Methoxyphenyl)-4-piperazinyl]butyl]-2-Methyl-4-thiazolidinone

试剂、催化剂与溶剂 1

HCID 6342乙腈溶剂

实验过程

A suspension of 2-methyl-3-(4-bromobutyl)-4-thiazolidinone (3.0 g), 1-(2-methoxyphenyl)piperazine (2.3 g) , anhydrous K2CO3 (3.5 g) and NaI (200 mg) in 100 ml of anhydrous CH3CN was heated to 80° under N2. After 4 hours no starting material remained as judged by TLC. The mixture was cooled to room temperature, filtered and concentrated in vauco. The residue was chromatographed on silica, using EtOAc as the eluent. This provided 2.18 g of product as a clear oil which solidified in vacuo (0.1 mmHg) overnight.

后处理

  1. temperaturewas heated to 80° under N2
  2. filtrationfiltered
  3. concentrationconcentrated in vauco
  4. customThe residue was chromatographed on silica
  5. customsolidified in vacuo (0.1 mmHg) overnight

来源与证据

ORD记录
ord-f4ab7e5f72ca43d88930029f82449402
来源数据集
uspto-grants-1994_12
专利号
US05371087

反应笔记

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