氢氧化钠 → 1-Acetyl-3-(2-hydroxyethyl)-4,6-dimethylindoline

HRID 1531968笔记

反应方程式

HRID 1531968 反应方程式
[C:1]([N:4]1[C:12]2[C:7](=[C:8]([CH3:14])[CH:9]=[C:10]([CH3:13])[CH:11]=2)[CH:6]([CH2:15][CH2:16][O:17]C(=O)C)[CH2:5]1)(=[O:3])[CH3:2].[OH-].[Na+]>C(Cl)(Cl)Cl.CO.O>[C:1]([N:4]1[C:12]2[C:7](=[C:8]([CH3:14])[CH:9]=[C:10]([CH3:13])[CH:11]=2)[CH:6]([CH2:15][CH2:16][OH:17])[CH2:5]1)(=[O:3])[CH3:2]

参与物

5

反应物 2

HCID 14798氢氧化钠HCID 222473471-Acetyl-3-(2-acetoxyethyl)-4,6-dimethylindoline

产物 1

HCID 222473161-Acetyl-3-(2-hydroxyethyl)-4,6-dimethylindoline收率 70.8%

试剂、催化剂与溶剂 2

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂HCID 21584188Chloroform methanol溶剂

实验过程

1-Acetyl-3-(2-acetoxyethyl)-4,6-dimethylindoline (2.0 g) was dissolved in a mixture of CHCl3/MeOH=1/1 (25 ml), and a solution of NaOH (1.5 g) in water (5 ml) was added, which was followed by stirring at room temperature for 1 hr. The solvent was evaporated under reduced pressure. CHCl3 (100 ml) was added, and the mixture was washed with water and dried over anhydrous sodium sulfate. CHCl3 was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: CHCl3/MeOH=50/1−10/1) to give 1.2 g of 1-acetyl-3-(2-hydroxyethyl)-4,6-dimethylindoline.

后处理

  1. customThe solvent was evaporated under reduced pressure
  2. additionCHCl3 (100 ml) was added
  3. washthe mixture was washed with water
  4. dry with materialdried over anhydrous sodium sulfate
  5. customCHCl3 was evaporated under reduced pressure
  6. customThe residue was purified by silica gel column chromatography (eluent: CHCl3/MeOH=50/1−10/1)

来源与证据

ORD记录
ord-9ff24629f6804f9d904842dec1160db5
来源数据集
uspto-grants-2001_03
专利号
US06200988B1

反应笔记

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