乙酰氧肟酸 → 4-甲氧基-1,2-苯并异恶唑-3-胺

HRID 16396笔记

反应方程式

HRID 16396 反应方程式
[C:1]([NH:4][OH:5])(=O)[CH3:2].CC(C)([O-])C.[K+].F[C:13]1[CH:20]=[CH:19]C=[C:17]([O:21][CH3:22])[C:14]=1C#N.[Cl-].[Na+].C[N:26](C)C=O>>[CH3:22][O:21][C:17]1[C:2]2[C:1]([NH2:26])=[N:4][O:5][C:19]=2[CH:20]=[CH:13][CH:14]=1

参与物

6

反应物 5

HCID 1990乙酰氧肟酸HCID 5234Halite (NaCl)HCID 6228N,N-二甲基甲酰胺HCID 5231012-氟-6-甲氧基苯腈HCID 23665647叔丁醇钾

产物 1

HCID 27797514-甲氧基-1,2-苯并异恶唑-3-胺

反应条件

温度
60 °C

实验过程

709.5 mg (9.45 mmol) of acetohydroxamic acid are initially charged in 8 ml of anhydrous dimethylformamide, and 1.06 g (9.45 mmol) of potassium tert-butoxide are added at room temperature. After 40 minutes of stirring, 1 g (6.62 mmol) of 2-fluoro-6-methoxybenzonitrile is added. The mixture is heated at 60° C. for 16 hours. 20 ml of saturated sodium chloride solution are then added to the reaction mixture. The precipitated crystals are filtered off with suction and washed with water.

后处理

  1. filtrationThe precipitated crystals are filtered off with suction
  2. washwashed with water

来源与证据

ORD记录
ord-acb4e7ee3dec4c4ea677ed50342c344e
来源数据集
uspto-grants-2010_06
专利号
US07737153B2

反应笔记

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