乙酰乙酸甲酯 → 2,5-二甲基-3-呋喃酸甲酯

HRID 1706339笔记

反应方程式

HRID 1706339 反应方程式
[C:1]([O:4][CH:5]([CH3:8])[CH:6]=O)(=O)[CH3:2].[C:9]([O:15][CH3:16])(=[O:14])[CH2:10]C(C)=O>[Fe].CO>[CH3:16][O:15][C:9]([C:10]1[CH:6]=[C:5]([CH3:8])[O:4][C:1]=1[CH3:2])=[O:14]

参与物

5

反应物 2

HCID 7757乙酰乙酸甲酯HCID 907281-FORMYLETHYL ACETATE

产物 1

HCID 802482,5-二甲基-3-呋喃酸甲酯

试剂、催化剂与溶剂 2

HCID 23925IRON催化剂HCID 887(5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮溶剂

实验过程

40 parts by weight of iron-III chloride and 136 parts by weight of 85 percent strength α-acetoxypropionaldehyde are added successively to a solution of 150 parts by weight of methyl acetoacetate in 120 parts by weight of methanol. The mixture, which becomes warm, is then refluxed for 2 hours. When it has cooled, the reaction solution is washed with water and distilled. 127 g of 2,5-dimethylfuran-3-carboxylic acid methyl ester are obtained.

后处理

  1. temperatureThe mixture, which becomes warm
  2. temperatureis then refluxed for 2 hours
  3. temperatureWhen it has cooled
  4. washthe reaction solution is washed with water
  5. distillationdistilled

来源与证据

ORD记录
ord-a86d7762caed427391b66ee59855b844
来源数据集
uspto-grants-1980_06
专利号
US04207243

反应笔记

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