氢氧化钠 → 2-(2-Chloro-2-propenyl)-5-(4-chlorobenzyl)-2-methylcyclopentanone

HRID 1752016笔记

反应方程式

HRID 1752016 反应方程式
COC([C:5]1([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)[CH2:9][CH2:8][C:7]([CH2:11][C:12]([Cl:14])=[CH2:13])([CH3:10])[C:6]1=[O:15])=O.[OH-].[Na+]>CC(O)C.O>[Cl:14][C:12](=[CH2:13])[CH2:11][C:7]1([CH3:10])[CH2:8][CH2:9][CH:5]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)[C:6]1=[O:15]

参与物

5

反应物 2

HCID 14798氢氧化钠HCID 86670684HCID 86670684，化合物2 次

产物 1

HCID 866706832-(2-Chloro-2-propenyl)-5-(4-chlorobenzyl)-2-methylcyclopentanone

试剂、催化剂与溶剂 2

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂2 次HCID 3776异丙醇溶剂

实验过程

3-(2-Chloro-2-propenyl)-1-(4-chlorobenzyl)-3-methyl-2-oxocyclopentane carboxylic acid methyl ester (Compound (XIII), R1=CH3, (Rb)Xbnb=CH2CCl═CH2, R2=CH3) (2.90 g, 8.16 mmol) was dissolved in i-PrOH (5 ml), and then an aqueous solution of NaOH (0.65 g, 16.3 mmol) dissolved in water (5.4 ml) was added, and stirring under reflux was conducted for 2.5 hours. Water (50 ml) was added, and extraction with hexane (50 ml×2) was conducted. The organic layer was dried over anhydrous sodium sulfate, and concentrated to obtain the desired substance

后处理

  1. additionwas added
  2. temperatureunder reflux
  3. extractionextraction with hexane (50 ml×2)
  4. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  5. concentrationconcentrated
  6. customto obtain the desired substance

来源与证据

ORD记录
ord-666d3de539ce4282ab114aca2ffd7d0e
来源数据集
uspto-grants-2015_10
专利号
US09162966B2

反应笔记

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