甲苯 → Bis(4-butoxyphenyl) sulfide

HRID 1753675

反应方程式

HRID 1753675 反应方程式
Br[CH2:2][CH2:3][CH2:4][CH3:5].[OH:6][C:7]1[CH:12]=[CH:11][C:10]([S:13][C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=2)=[CH:9][CH:8]=1.C(=O)([O-])[O-].[K+].[K+].CN(C=O)C.[C:32]1(C)[CH:37]=CC=[CH:34][CH:33]=1>O>[CH2:2]([O:20][C:17]1[CH:18]=[CH:19][C:14]([S:13][C:10]2[CH:11]=[CH:12][C:7]([O:6][CH2:37][CH2:32][CH2:33][CH3:34])=[CH:8][CH:9]=2)=[CH:15][CH:16]=1)[CH2:3][CH2:4][CH3:5]

参与物

7

反应物 5

HCID 1140甲苯HCID 6228N,N-二甲基甲酰胺HCID 8002溴丁烷HCID 11430碳酸钾HCID 175704,4'-二羟基二苯硫醚

产物 1

HCID 117666789Bis(4-butoxyphenyl) sulfide收率 99.1%

试剂、催化剂与溶剂 1

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂

实验过程

A solution was prepared by combining 107 g of bromobutane, 76 g of bis(4-hydroxyphenyl) sulfide, 108 g of potassium carbonate, and 230 g of DMF. The solution was aged at 90° C. for 16 hours. The aged solution was cooled to room temperature, to which 600 g of water was added to quench the reaction. To the solution was added 300 g of toluene. The organic layer was separated, washed with water, and concentrated in vacuum, obtaining 114 g of the target compound, bis(4-butoxyphenyl) sulfide as amorphous solid. Yield 99%.

后处理

  1. customA solution was prepared
  2. additionwas added
  3. customto quench
  4. customthe reaction
  5. customThe organic layer was separated
  6. washwashed with water
  7. concentrationconcentrated in vacuum

来源与证据

ORD记录
ord-607339dd48344dbc9f8a8a7744528260
来源数据集
uspto-grants-2015_10
专利号
US09164384B2

关联笔记

加载中…