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N,N-二甲基甲酰胺 → HCID 117666823,化合物

HRID 1753677
笔记
打印预览

反应方程式

HRID 1753677 反应方程式
[C:1]1([S:7][C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21].C(=O)([O-])[O-].[K+].[K+].CN(C=O)C>C1(C)C=CC=CC=1.O>[C:1]1([S:7][C:8]2[CH:13]=[CH:12][C:11]([O:14][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])=[CH:10][CH:9]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1
参与物实验过程后处理来源与证据反应笔记

参与物

7

反应物 4

HCID 6228N,N-二甲基甲酰胺HCID 8101溴己烷HCID 11430碳酸钾HCID 113101954-羟基苯基苯硫醚

产物 1

HCID 117666823HCID 117666823,化合物收率 90%

试剂、催化剂与溶剂 2

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂
HCID 1140
甲苯
溶剂

实验过程

A solution was prepared by combining 15 g of (4-hydroxyphenyl) phenyl sulfide which had been synthesized according to the well-known formulation, 11 g of 1-bromohexane, 9 g of potassium carbonate, and 30 g of DMF. The solution was aged at 80° C. for 16 hours. The aged solution was cooled to room temperature, to which 30 g of water was added to quench the reaction. To the solution, 50 g of toluene was added for extraction. The organic layer was separated and washed with sodium hydroxide aqueous solution and water in sequence. On subsequent concentration in vacuum, 16 g of the target compound, (4-hexyloxyphenyl) phenyl sulfide was obtained as oily matter. Yield 90%.

后处理

  1. customA solution was prepared
  2. customhad been synthesized
  3. additionwas added
  4. customto quench
  5. customthe reaction
  6. customThe organic layer was separated
  7. washwashed with sodium hydroxide aqueous solution and water in sequence
  8. concentrationOn subsequent concentration in vacuum, 16 g of the target compound

来源与证据

ORD记录
ord-88a342cc91cc40d68d522657fb1c9b58
来源数据集
uspto-grants-2015_10
DOI
10.6084/m9.figshare.5104873.v1
专利号
US09164384B2

反应笔记

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本页导航参与物实验过程后处理来源与证据反应笔记