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盐酸 → HCID 117666944,化合物

HRID 1753679
笔记
打印预览

反应方程式

HRID 1753679 反应方程式
[C:1]1([S:7][C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1.C(=O)([O-])[O-].[K+].[K+].Cl>C1(C)C=CC=CC=1.CN(C=O)C>[C:1]1([S:7][C:8]2[CH:13]=[CH:12][C:11]([O:14][CH:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)=[CH:10][CH:9]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1
参与物实验过程后处理来源与证据反应笔记

参与物

7

反应物 4

HCID 313盐酸HCID 8728溴代环戊烷HCID 11430碳酸钾HCID 113101954-羟基苯基苯硫醚

产物 1

HCID 117666944HCID 117666944,化合物收率 100%

试剂、催化剂与溶剂 2

HCID 1140甲苯溶剂HCID 6228N,N-二甲基甲酰胺
溶剂

实验过程

A solution was prepared by combining 11.3 g of 4-hydroxyphenyl phenyl sulfide which had been synthesized according to the well-known formulation, 8.2 g of bromocyclopentane, 7.6 g of potassium carbonate, and 40 g of DMF. The solution was aged at 80° C. for 16 hours. The aged solution was cooled to room temperature, to which 100 g of 5 wt % dilute hydrochloric acid was added to quench the reaction. To the solution, 150 g of toluene was added for extraction. The organic layer was separated and washed with water. It was combined with 5 wt % sodium hydroxide aqueous solution. The organic layer was separated and washed with water again. On subsequent concentration in vacuum, 13.8 g of the target compound, 4-cyclopentyloxyphenyl phenyl sulfide was obtained as oily matter. Yield 100%.

后处理

  1. customA solution was prepared
  2. customhad been synthesized
  3. additionwas added
  4. customto quench
  5. customthe reaction
  6. customThe organic layer was separated
  7. washwashed with water
  8. customThe organic layer was separated
  9. washwashed with water again
  10. concentrationOn subsequent concentration in vacuum, 13.8 g of the target compound

来源与证据

ORD记录
ord-eebf25671ab942169514c84b14c004ce
来源数据集
uspto-grants-2015_10
DOI
10.6084/m9.figshare.5104873.v1
专利号
US09164384B2

反应笔记

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本页导航参与物实验过程后处理来源与证据反应笔记