乙酐 → N-(2,3-Dihydro-1H-inden-2-yl)formamide

HRID 1761868笔记

反应方程式

HRID 1761868 反应方程式
C(O[C:5](=[O:7])C)(=O)C.Cl.[NH2:9][CH:10]1[CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11]1.C([O-])(=O)C.[Na+]>C(O)=O>[CH:5]([NH:9][CH:10]1[CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11]1)=[O:7]

参与物

5

反应物 3

HCID 7918乙酐HCID 1227642-Aminoindan hydrochlorideHCID 517045醋酸钠

产物 1

HCID 14835235N-(2,3-Dihydro-1H-inden-2-yl)formamide

试剂、催化剂与溶剂 1

HCID 284甲酸溶剂

实验过程

Acetic anhydride (40 ml) and formic acid (20 ml) were mixed and heated at 50° for 15 minutes with stirring. 2-Aminoindane hydrochloride (25 g) (see J. Med. Chem., 1980, 23, page 745) and sodium acetate (20 g) were added to this mixture which was then stirred at room temperature for 24 hours. The reaction mixture was poured into ice/water and extracted three times with methylene chloride. The combined organic layers were washed with water and aqueous sodium carbonate, dried (MgSO4) and evaporated in vacuo to give the title compound, yield 17.6 g, m.p. 72°-74°.

后处理

  1. temperatureheated at 50° for 15 minutes
  2. stirringwas then stirred at room temperature for 24 hours
  3. extractionextracted three times with methylene chloride
  4. washThe combined organic layers were washed with water and aqueous sodium carbonate
  5. dry with materialdried (MgSO4)
  6. customevaporated in vacuo

来源与证据

ORD记录
ord-d94d974fd50549f19dafb663a42b72e0
来源数据集
uspto-grants-1989_05
专利号
US04829071

反应笔记

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