Hydrogen Peroxide → 4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]-2-[2-(2-hydroxyethoxy)ethylamino]benzamide

HRID 1877443

反应方程式

HRID 1877443 反应方程式
F[C:2]1[CH:9]=[C:8]([N:10]2[C:22]3[CH:21]=[CH:20][CH:19]=[C:18]([C:23]4[NH:27][C:26]5[CH:28]=[C:29]([F:32])[CH:30]=[CH:31][C:25]=5[N:24]=4)[C:17]=3[C:16]3[C:11]2=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].C(=O)([O-])[O-:34].[K+].[K+].[NH2:39][CH2:40][CH2:41][O:42][CH2:43][CH2:44][OH:45].[OH-].[Na+].OO>CS(C)=O.C(O)C>[F:32][C:29]1[CH:30]=[CH:31][C:25]2[N:24]=[C:23]([C:18]3[C:17]4[C:16]5[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=5)[N:10]([C:8]5[CH:7]=[CH:6][C:3]([C:4]([NH2:5])=[O:34])=[C:2]([NH:39][CH2:40][CH2:41][O:42][CH2:43][CH2:44][OH:45])[CH:9]=5)[C:22]=4[CH:21]=[CH:20][CH:19]=3)[NH:27][C:26]=2[CH:28]=1

参与物

8

反应物 5

HCID 784Hydrogen PeroxideHCID 11430碳酸钾HCID 13578二甘醇胺HCID 14798二甲基对苯二胺二盐酸HCID 583383582-fluoro-4-[4-(6-fluoro-1H-benzimidazol-2-yl)carbazol-9-yl]benzonitrile

产物 1

HCID 442237854-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]-2-[2-(2-hydroxyethoxy)ethylamino]benzamide

试剂、催化剂与溶剂 2

HCID 679二甲基亚砜溶剂HCID 702乙醇溶剂

实验过程

The process is carried out as in stage 3 of Example 3, but using 84 mg of 2-fluoro-4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]benzonitrile, obtained according to stage 2 of Example 3, 83 mg of potassium carbonate and 421 mg of 2-(2-aminoethoxy)ethanol in 0.67 ml of dimethyl sulphoxide. 0.4 ml of a 1M aqueous solution of sodium hydroxide, 0.4 ml of a 30% aqueous solution of hydrogen peroxide and 2 ml of ethanol are then added to the reaction medium. After treatment and purification as in stage 3 of Example 3, 76 mg of 4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]-2-[2-(2-hydroxyethoxy)ethylamino]benzamide are thus obtained in the form of a white solid, the characteristics of which are the following:

后处理

  1. customobtained
  2. customAfter treatment and purification as in stage 3 of Example 3, 76 mg of 4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]-2-[2-(2-hydroxyethoxy)ethylamino]benzamide
  3. customare thus obtained in the form of a white solid

来源与证据

ORD记录
ord-85ca477f6f45427da7addb6ba31228c9
来源数据集
uspto-grants-2012_11
专利号
US08309721B2

关联笔记

加载中…