2-氨基-4'-氟苯乙酮 → 2-氨基-1-(4-氟苯基)乙醇

HRID 1908256笔记

反应方程式

HRID 1908256 反应方程式
[NH2:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1)=[O:4].[BH4-].[Na+]>CO>[NH2:1][CH2:2][CH:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1)[OH:4]

参与物

4

反应物 2

HCID 15811772-氨基-4'-氟苯乙酮HCID 4311764硼氢化钠

产物 1

HCID 98272-氨基-1-(4-氟苯基)乙醇收率 100%

试剂、催化剂与溶剂 1

HCID 887(5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮溶剂

实验过程

To a solution consisting of 2-amino-1-(4-fluoro-phenyl)-ethanone (150 mg, 0.9 mmol) and MeOH (5 mL) was added NaBH4 (97 mg, 2.6 mmol). The mixture was stirred at rt for 45 min and then concentrated to dryness. The residue was diluted with EtOAc and washed with a satd. NH4Cl solution before drying (Na2SO4), and concentrating to give 2-amino-1-(4-fluoro-phenyl)-ethanol (139 mg, 100%) which was used without further purification.

后处理

  1. concentrationconcentrated to dryness
  2. additionThe residue was diluted with EtOAc
  3. washwashed with a satd
  4. dry with materialNH4Cl solution before drying (Na2SO4)
  5. concentrationconcentrating

来源与证据

ORD记录
ord-3de15211aafd4142a970ccbc6622e103
来源数据集
uspto-grants-2013_12
专利号
US08598202B2

反应笔记

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