高锰酸钾 → HCID 67027109，化合物

HRID 1908809笔记

反应方程式

HRID 1908809 反应方程式
[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([CH2:9][OH:10])[CH:3]=1.[O-:11][Mn](=O)(=O)=O.[K+:16]>CC(C)=O>[K+:16].[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]([O-:11])=[O:10])[CH:3]=1

参与物

4

反应物 2

HCID 516875高锰酸钾HCID 670270074-溴-6-甲基吡啶-2-甲醇

产物 1

HCID 67027109HCID 67027109，化合物收率 116%

试剂、催化剂与溶剂 1

HCID 180丙酮溶剂

反应条件

温度
40 °C

实验过程

To a solution of (4-bromo-6-methyl-pyridin-2-yl)-methanol (1.31 g, 6.48 mmol) in acetone (150 mL), KMnO4 (2.61 g, 16.5 mmol) is added. The mixture is stirred at 40° C. for 2 h before it is filtered over a sintered glass funnel. The filtrate is evaporated to dryness, the remaining solid is washed with water and dried under HV to give 4-bromo-6-methyl-pyridine-2-carboxylic acid potassium salt (1.91 g) as a white solid; LC-MS: tR=0.45 min, [M+1]+=217.89.

后处理

  1. filtrationis filtered over a sintered glass funnel
  2. customThe filtrate is evaporated to dryness
  3. washthe remaining solid is washed with water
  4. customdried under HV

来源与证据

ORD记录
ord-b33b130f2686450eab5df7b6cf7d7ac1
来源数据集
uspto-grants-2013_12
专利号
US08598208B2

反应笔记

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