Carbonic acid sodium salt (1:2) → Diethyl 5-hydroxypentylphosphonate

HRID 2012笔记

反应方程式

HRID 2012 反应方程式
C([O:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][P:10]([O:15][CH2:16][CH3:17])([O:12][CH2:13][CH3:14])=[O:11])(=O)C.C(=O)([O-])[O-].[Na+].[Na+]>CO>[OH:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][P:10](=[O:11])([O:12][CH2:13][CH3:14])[O:15][CH2:16][CH3:17]

参与物

4

反应物 2

HCID 10340Carbonic acid sodium salt (1:2)HCID 196892225-(Diethylphosphono)pentyl acetate

产物 1

HCID 10680635Diethyl 5-hydroxypentylphosphonate

试剂、催化剂与溶剂 1

HCID 887(5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮溶剂

实验过程

92 g (0.345 mol) of 5-(diethylphosphono)pentyl acetate were heated at 50° C. for 10 hours with stirring with 74 g (0.7 mol) of finely powdered sodium carbonate in 500 ml of methanol. The solution was filtered, concentrated and distilled in a bulb tube.

后处理

  1. filtrationThe solution was filtered
  2. concentrationconcentrated
  3. distillationdistilled in a bulb tube

来源与证据

ORD记录
ord-c88ff47b784b42e596807b91fc6e4cda
来源数据集
uspto-grants-1998_03
专利号
US05728686

反应笔记

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