碳酸钾 → 2-(2-氯乙氧基)苯磺酰胺

HRID 2118928笔记

反应方程式

HRID 2118928 反应方程式
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:10])=[O:9].C(=O)([O-])[O-].[K+].[K+].C1(C)C=CC(C(S(O[CH2:30][CH2:31][Cl:32])(=O)=O)=O)=CC=1>C(C(C)=O)C>[Cl:32][CH2:31][CH2:30][O:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:9])=[O:10]

参与物

5

反应物 3

HCID 11430碳酸钾HCID 637546邻羟基苯磺酰胺HCID 539698672-Chloroethyl p-toloylsulfonate

产物 1

HCID 137294542-(2-氯乙氧基)苯磺酰胺

试剂、催化剂与溶剂 1

HCID 6569Methyl Ethyl Ketone溶剂

实验过程

A mixture of 9.0 g of 2-hydroxyphenylsulfonamide, 7.9 g of potassium carbonate, 13.3 g of 2-chloroethyl p-toloylsulfonate and 80 ml of ethylmethylketone is refluxed for 40 hours. The reaction mixture is cooled to room temperature, filtrated and evaporated to dryness. From the oily residue crystallise after addition of a small portion of methylene chloride 7.0 g of 2-(2-chloroethoxy)-phenylsulfonamide, m.p. 110° C.

后处理

  1. temperatureis refluxed for 40 hours
  2. filtrationfiltrated
  3. customevaporated to dryness
  4. customFrom the oily residue crystallise
  5. additionafter addition of a small portion of methylene chloride 7.0 g of 2-(2-chloroethoxy)-phenylsulfonamide, m.p. 110° C.

来源与证据

ORD记录
ord-086e0da574614fe2b03935b0070c2db1
来源数据集
uspto-grants-1987_07
专利号
US04681619

反应笔记

加载中…