四氧化硫 → 61706-47-6

HRID 2219082笔记

反应方程式

HRID 2219082 反应方程式
[N+:1]([C:4]1[CH:19]=[CH:18][C:7]([C:8]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)([CH3:11])[C:9]#[N:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].S(=O)(=O)(O)[OH:21].[OH-].[Na+]>>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([C:8]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)([CH3:11])[C:9]([NH2:10])=[O:21])=[CH:18][CH:19]=1)([O-:3])=[O:2]

参与物

4

反应物 3

HCID 1118四氧化硫HCID 14798氢氧化钠HCID 2110592-(4-Nitrophenyl)-2-phenylpropanenitrile

产物 1

HCID 304617961706-47-6

实验过程

) A mixture of 0.020 mol of p-nitro-α-phenylhydratroponitrile and 28 ml of concentrated sulfuric acid solution (90%) is heated in a water-bath for 3.5 hours. The reaction mixture is poured onto crushed ice, neutralized with a sodium hydroxide solution and the product is extracted with chloroform. The organic layer is washed with water, dried and evaporated in vacuo and the residue is crystallized from ether, yielding 2.4 grams of p-nitro-α-phenylhydratropamide. (interm. 7)

后处理

  1. temperatureis heated in a water-bath for 3.5 hours
  2. additionThe reaction mixture is poured
  3. customonto crushed ice
  4. extractionthe product is extracted with chloroform
  5. washThe organic layer is washed with water
  6. customdried
  7. customevaporated in vacuo
  8. customthe residue is crystallized from ether

来源与证据

ORD记录
ord-84c90870540c4400978c5e456b8b41ca
来源数据集
uspto-grants-2008_08
专利号
US07414048B2

反应笔记

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