碳酸钾 → 3-(2-Chloro-5-pyridylmethyl)-2-(nitroimino)thiazolidine

HRID 22216

反应方程式

HRID 22216 反应方程式
[N+:1]([N:4]=[C:5]1[NH:9][CH2:8][CH2:7][S:6]1)([O-:3])=[O:2].C(=O)([O-])[O-].[K+].[K+].[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23]Cl)=[CH:19][N:18]=1>C(#N)C>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][N:9]2[CH2:8][CH2:7][S:6][C:5]2=[N:4][N+:1]([O-:3])=[O:2])=[CH:19][N:18]=1

参与物

5

反应物 3

HCID 11430碳酸钾HCID 1554792-氯-5-氯甲基吡啶HCID 1362474392-Nitroiminothiazolidine

产物 1

HCID 538802633-(2-Chloro-5-pyridylmethyl)-2-(nitroimino)thiazolidine

试剂、催化剂与溶剂 1

HCID 6342乙腈溶剂

实验过程

A mixture of 2.9 g of 2-nitroiminothiazolidine, 2.9 g of anhydrous potassium carbonate, 3.2 g of 2-chloro-5-pyridylmethylchloride and 50 ml of acetonitrile was refluxed for 5 hours with vigorously stirring. After the reaction, most of the acetonitrile was removed by distillation and water was added to the residue. As the solid product was separated, it was collected by filtration. The crude material was recrystallized from ethanol to give desired 3-(2-chloro-5-pyridylmethyl)-2-(nitroimino)thiazolidine.

后处理

  1. temperaturewas refluxed for 5 hours
  2. customAfter the reaction
  3. custommost of the acetonitrile was removed by distillation and water
  4. additionwas added to the residue
  5. customAs the solid product was separated
  6. filtrationit was collected by filtration
  7. customThe crude material was recrystallized from ethanol

来源与证据

ORD记录
ord-b9abcddd57be425a9b079fbae3721260
来源数据集
uspto-grants-1995_06
专利号
US05428032

关联笔记

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