三乙胺 → Ethyl 4-(3-(2,6-dimethylbenzyloxy)phenyl)-3-butenoate

HRID 25035笔记

反应方程式

HRID 25035 反应方程式
C(N(CC)CC)C.[CH3:8][C:9]1[CH:31]=[CH:30][CH:29]=[C:28]([CH3:32])[C:10]=1[CH2:11][O:12][C:13]1[CH:14]=[C:15]([CH:19](Br)[CH2:20][CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH:16]=[CH:17][CH:18]=1>C(Cl)(Cl)(Cl)Cl>[CH3:32][C:28]1[CH:29]=[CH:30][CH:31]=[C:9]([CH3:8])[C:10]=1[CH2:11][O:12][C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH:16]=[CH:17][CH:18]=1

参与物

4

反应物 2

HCID 8471三乙胺HCID 21964551Ethyl 4-(3-(2,6-dimethylbenzyloxy)phenyl)-4-bromobutyrate

产物 1

HCID 67274119Ethyl 4-(3-(2,6-dimethylbenzyloxy)phenyl)-3-butenoate

试剂、催化剂与溶剂 1

HCID 5943四氯化碳溶剂

实验过程

Add Triethylamine to a solution of Ethyl 4-(3-(2,6-dimethylbenzyloxy)phenyl)-4-bromobutyrate (Step E) in carbon tetrachloride. After stirring approximately for 4 hours, the mixture can be filtered through a pad of silica gel few times, and concentrate to give the title compound.

后处理

  1. filtrationthe mixture can be filtered through a pad of silica gel few times
  2. concentrationconcentrate

来源与证据

ORD记录
ord-498751129cd4437dbc650b66414989b5
来源数据集
uspto-grants-2005_02
专利号
US06858602B2

反应笔记

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