Government regulation → 7-Bromo-5-chloro-2,3-dihydrobenzofuran

HRID 257516笔记

反应方程式

HRID 257516 反应方程式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1.[Br:11]Br.S([O-])([O-])(=O)=S.[Na+].[Na+]>C(O)(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([Br:11])[C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1

参与物

5

反应物 3

HCID 24408Government regulationHCID 24477硫代硫酸钠HCID 5929645-氯-2,3-二氢苯并呋喃

产物 1

HCID 197834187-Bromo-5-chloro-2,3-dihydrobenzofuran收率 92%

试剂、催化剂与溶剂 1

HCID 176醋酸溶剂2 次

实验过程

To a stirred solution of (33) (1.84 g, 11.93 mmol) in acetic acid (10 ml) at 0° C., was slowly added a solution of bromine (1.24 ml, 24 mmol) in acetic acid (5 ml). The reaction mixture was stirred at room temperature for 4.5 h. A 10% sodium thiosulphate solution (70 ml) was added and the mixture stirred for 10 min. The bulk of the solvent was evaporated in vacuo. The resulting oil was dissolved in ether (50 ml), washed with water (20 ml), saturated NaHCO2 (2×15 ml), brine (1×15 ml), dried Na2SO4 and evaporated in vacuo to give 2.55 g (92%) of (34) as a oil.

后处理

  1. stirringthe mixture stirred for 10 min
  2. customThe bulk of the solvent was evaporated in vacuo
  3. dissolutionThe resulting oil was dissolved in ether (50 ml)
  4. washwashed with water (20 ml), saturated NaHCO2 (2×15 ml), brine (1×15 ml), dried Na2SO4
  5. customevaporated in vacuo

来源与证据

ORD记录
ord-f2c2ef8aac97430eba3688d429ad02ec
来源数据集
uspto-grants-1993_11
专利号
US05262430

反应笔记

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