碘化钾 → Ethyl 2-(p-chlorobenzylthio)-propionate

HRID 26803

反应方程式

HRID 26803 反应方程式
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][SH:7])=[CH:4][CH:3]=1.Br[CH:11]([CH3:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CC(C)=O>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][S:7][CH:11]([CH3:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:4][CH:3]=1

参与物

6

反应物 4

HCID 4875碘化钾HCID 11430碳酸钾HCID 790402-溴丙酸乙酯HCID 804094-氯苄硫醇

产物 1

HCID 20542836Ethyl 2-(p-chlorobenzylthio)-propionate

试剂、催化剂与溶剂 1

HCID 180丙酮溶剂

实验过程

A mixture of 19.5 ml (0.15 mol) of 4-chlorobenzylmercaptan, 27.1 g (0.15 mol) of ethyl α-bromopropionate, 21 g of potassium carbonate and 0.1 g of potassium iodide in 100 ml of anhydrous acetone is kept under reflux for 6 hrs. It is filtered, the precipitate is washed with acetone and the filtrate is evaporated in vacuo. 200 ml of ether are added to the residue and the mixture is washed with dilute NaOH, dilute HCl and water, dried and evaporated in vacuo.

后处理

  1. temperatureunder reflux for 6 hrs
  2. filtrationIt is filtered
  3. washthe precipitate is washed with acetone
  4. customthe filtrate is evaporated in vacuo
  5. addition200 ml of ether are added to the residue
  6. washthe mixture is washed with dilute NaOH, dilute HCl and water
  7. customdried
  8. customevaporated in vacuo

来源与证据

ORD记录
ord-6b43ab3bf0e845f9a5b625b6edc154b7
来源数据集
uspto-grants-1979_04
专利号
US04151300

关联笔记

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