盐酸 → 4-甲基-2-(4-吡啶基)噻唑-5-羧酸
反应方程式
[CH3:1][C:2]1[N:3]=[C:4]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[S:5][C:6]=1[C:7]([O:9]CC)=[O:8].[OH-].[Na+].O1CCCC1CCO.Cl>O>[CH3:1][C:2]1[N:3]=[C:4]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[S:5][C:6]=1[C:7]([OH:9])=[O:8]参与物
6
实验过程
A mixture of ethyl 4-methyl-2-(4-pyridyl)thiazole-5-carboxylate (744 mg), 1 N NaOH (4 ml) and tetrahydrofuran-ethanol (1:1, 6 ml) was stirred at room temperature for 1 hour and diluted with water, to which was added 1 N hydrochloric acid (4 ml) to give the title compound as crystals (595 mg, 90.2%).
来源与证据
- ORD记录
- ord-25cf9bce5db940d682c21e88c8adc033
- 来源数据集
- uspto-grants-2002_03
- 专利号
- US06359134B1
反应笔记
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