苯甲醇 → 苯甲酸

HRID 28186笔记

反应方程式

HRID 28186 反应方程式
I([O-])(=O)(=O)=[O:2].[Na+].[CH2:7]([OH:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>[OH-].[Na+].[Ru](=O)=O>[C:7]([OH:2])(=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

参与物

5

反应物 2

HCID 244苯甲醇HCID 23667635高碘酸钠

产物 1

HCID 243苯甲酸收率 89%

试剂、催化剂与溶剂 2

HCID 82848二氧化钌催化剂HCID 14798氢氧化钠溶剂

实验过程

To a stirred suspension of 20 g (94 m mol) sodium periodate in 200 cc of 1 molar sodium hydroxide there was added 0.1 g (0.75 m mol) ruthenium dioxide and 4.32 g (40 m mol) benzyl alcohol. After two hours the reaction was stopped. The mixture was then filtered and the filtrate washed with ether obtaining a neutral fraction comprising benzaldehyde and unreacted benzyl alcohol. The aqueous alkali phase was acidified with sulfuric acid and extracted with ether. There was obtained 4.32 grams of benzoic acid (89% yield).

后处理

  1. filtrationThe mixture was then filtered
  2. washthe filtrate washed with ether obtaining a neutral fraction comprising benzaldehyde and unreacted benzyl alcohol
  3. extractionextracted with ether

来源与证据

ORD记录
ord-6ede1a92eed94cd3931b64ec1fd29d22
来源数据集
uspto-grants-1980_09
专利号
US04225694

反应笔记

加载中…