对羟基苯甲醛 → 4,4'-(丙烷-1,3-二基双(氧基))二苯甲醛

HRID 3025

反应方程式

HRID 3025 反应方程式
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.Br[CH2:11][CH2:12][CH2:13]Br>C(=O)([O-])[O-].[K+].[K+].CN(C=O)C>[CH:6]([C:5]1[CH:8]=[CH:9][C:2]([O:1][CH2:11][CH2:12][CH2:13][O:1][C:2]2[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=2)=[CH:3][CH:4]=1)=[O:7]

参与物

5

反应物 2

HCID 126对羟基苯甲醛HCID 80011,3-二溴丙烷

产物 1

HCID 64229124,4'-(丙烷-1,3-二基双(氧基))二苯甲醛收率 76%

试剂、催化剂与溶剂 2

HCID 6228N,N-二甲基甲酰胺溶剂HCID 11430碳酸钾溶剂

实验过程

10.0 g of 4-hydroxybenzaldehyde and 8.3 g of 1,3-dibromopropane were reacted for 24 hours in 6.2 g of potassium carbonate solution in 100 ml of DMF under reflux. The reaction mixture was poured into cold distilled water to obtain a precipitate. After filtration and vacuum drying the precipitate, the resultant was recrystallized in ethanol to obtain the white product (XII-1). The product yield was 76%.

后处理

  1. temperatureunder reflux
  2. additionThe reaction mixture was poured
  3. distillationinto cold distilled water
  4. customto obtain a precipitate
  5. filtrationAfter filtration and vacuum
  6. customdrying the precipitate
  7. customthe resultant was recrystallized in ethanol
  8. customto obtain the white product (XII-1)

来源与证据

ORD记录
ord-db854b27d2914399bbe5f288a9a9adb4
来源数据集
uspto-grants-1998_03
专利号
US05731599

关联笔记

加载中…