天然气 → 3-(3,4,5-三甲氧基苯基)丙酸

HRID 325022

反应方程式

HRID 325022 反应方程式
[C:1](=[O:4])([O-])[O-:2].[K+].[K+].[CH3:7][O:8][C:9]1[CH:10]=[C:11]([C:19](=C)[C:20](O)=O)[CH:12]=[C:13]([O:17][CH3:18])[C:14]=1[O:15][CH3:16].C>[Pd].O>[CH3:18][O:17][C:13]1[CH:12]=[C:11]([CH2:19][CH2:20][C:1]([OH:2])=[O:4])[CH:10]=[C:9]([O:8][CH3:7])[C:14]=1[O:15][CH3:16]

参与物

6

反应物 3

HCID 297天然气HCID 11430碳酸钾HCID 208491922-(3,4,5-Trimethoxyphenyl)prop-2-enoic acid

产物 1

HCID 648603-(3,4,5-三甲氧基苯基)丙酸收率 167.5%

试剂、催化剂与溶剂 2

HCID 23938钯催化剂HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂

实验过程

6.8 g of potassium carbonate is added to a solution of 21.44 g of 3,4,5-trimethoxyphenylpropenoic acid and 45 ml of water then the medium is hydrogenated for one hour under a pressure of 1200-1300 mbars in the presence of 1.8 g activated charcoal with 10% palladium, in this way 2.1 l of hydrogen is absorbed. The reaction medium is filtered, followed by washing with water and acidifying with 50 ml of hydrochloric acid (2N). After separation, the residue is washed with water and dried under reduced pressure at ambient temperature. In this way 19.8 g of the expected product is obtained (M.P.=102-103° C.).

后处理

  1. customin this way 2.1 l of hydrogen is absorbed
  2. filtrationThe reaction medium is filtered
  3. washby washing with water and acidifying with 50 ml of hydrochloric acid (2N)
  4. customAfter separation
  5. washthe residue is washed with water
  6. customdried under reduced pressure at ambient temperature

来源与证据

ORD记录
ord-8cc873cd4ee7468f94dde1f576824c0e
来源数据集
uspto-grants-2001_04
专利号
US06221907B1

关联笔记

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