1-Bromopropane → 1-Bromo-2-methoxy-4-propoxybenzene
反应方程式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[O:9][CH3:10].Br[CH2:12][CH2:13][CH3:14].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:12][CH2:13][CH3:14])=[CH:4][C:3]=1[O:9][CH3:10]参与物
6
反应条件
- 温度
- 80 °C
实验过程
1.50 g (7.39 mmol) 4-bromo-3-methoxy-phenol are added to 1.36 g (11.1 mmol) 1-bromopropane in 10 mL DMF. 2.04 g (14.8 mmol) K2CO3 are added and the mixture is stirred at 80° C. for 12 h. After that time, the mixture is diluted with water and extracted with DCM. The organic layer is dried over sodium sulphate and the solvent is removed in vacuo.
后处理
- extractionextracted with DCM
- dry with materialThe organic layer is dried over sodium sulphate
- customthe solvent is removed in vacuo
来源与证据
- ORD记录
- ord-9a1efe617e9941eab7eea8d90018e4c0
- 来源数据集
- uspto-grants-2014_11
- 专利号
- US08877754B2
反应笔记
加载中…