克拉维酸 → 克拉维酸钾

HRID 342856

反应方程式

HRID 342856 反应方程式
C([NH2+]CC[NH2+]C(C)C)(C)C.[CH2:11]1[C:14](=[O:15])[N:13]2[C@@H:16]([C:22]([OH:24])=[O:23])/[C:17](/[O:21][C@H:12]12)=[CH:18]/[CH2:19][OH:20].C(C(CCCC)C([O-])=O)C.[K+:35]>O.C(O)(C)C>[CH2:11]1[C:14](=[O:15])[N:13]2[C@@H:16]([C:22]([O-:24])=[O:23])/[C:17](/[O:21][C@H:12]12)=[CH:18]/[CH2:19][OH:20].[K+:35]

参与物

6

反应物 3

HCID 5280980克拉维酸HCID 7017225N,N'-diisopropylethylenediammoniumHCID 23669619Potassium 2-ethylhexanoate

产物 1

HCID 23665591克拉维酸钾收率 70%

试剂、催化剂与溶剂 2

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂HCID 3776异丙醇溶剂2 次

实验过程

N,N'-diisopropylethylenediammonium diclavulanate (10 g, clavulanic acid content 69%) was dissolved in water (10 ml), the solution was diluted with isopropanol (190 ml) and a solution (15 ml, 2M) of potassium 2-ethylhexanoate in isopropanol was added within 15 min. with stirring. The obtained suspension was stirred for another 30 min. whereat a precipitate separated, which was filtered off, washed with isopropanol and then dried. Thus there was obtained potassium clavulanate (4.8 g; 70%), (USP Grade, clavulanic acid content 81% as determined by the HPLC method).

后处理

  1. stirringThe obtained suspension was stirred for another 30 min. whereat a precipitate
  2. customseparated
  3. filtrationwhich was filtered off
  4. washwashed with isopropanol
  5. customdried

来源与证据

ORD记录
ord-721114bda9274c088024b46e36b62efc
来源数据集
uspto-grants-1999_01
专利号
US05859238

关联笔记

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