反应方程式
[F:1][C:2]([F:12])([F:11])[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.C([O:15][C:16](=[O:23])[C@H:17]([CH2:19][CH:20]([CH3:22])[CH3:21])[NH2:18])C.C([O-])([O-])=O.[K+:28].[K+]>CO>[K+:28].[F:1][C:2]([F:12])([F:11])[C:3](=[N:18][C@H:17]([C:16]([O-:23])=[O:15])[CH2:19][CH:20]([CH3:22])[CH3:21])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1参与物
5
反应条件
- 温度
- 50 °C
实验过程
2,2,2-Trifluoroacetophenone (4.24 g, 24.3 mmol) was added to a mixture of L-leucine ethyl ester (3.52 g, 22.1 mmol) and K2CO3 (2.90 g, 20.9 mmol) in MeOH (50 mL). The mixture was warmed to 50° C. for 18 h. The mixture was cooled to 20–25° C., filtered and concentrated. The residue was suspended in TBME (100 ml) and filtered to give the title compound as a white solid.
后处理
- temperatureThe mixture was cooled to 20–25° C.
- filtrationfiltered
- concentrationconcentrated
- filtrationfiltered
来源与证据
- ORD记录
- ord-5f92f863da7b42ef84344f9dca9f82b5
- 来源数据集
- uspto-grants-2007_02
- 专利号
- US07183425B2
关联笔记
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