对氯苯酚 → 1-(4-氯苯氧基)-4-硝基苯

HRID 35688

反应方程式

HRID 35688 反应方程式
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=1.C(=O)([O-])[O-].[K+].[K+]>CS(C)=O>[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=2)=[CH:14][CH:13]=1

参与物

5

反应物 3

HCID 4684对氯苯酚HCID 9590对氟硝基苯HCID 11430碳酸钾

产物 1

HCID 157861-(4-氯苯氧基)-4-硝基苯收率 702.3%

试剂、催化剂与溶剂 1

HCID 679二甲基亚砜溶剂

反应条件

温度
70 °C

实验过程

Under a dry nitrogen atmosphere a stirred mixture of 10.9 g (0.077 mole) 4-fluoronitrobenzene, 9.95 g (0.0077 mole) 4-chlorophenol, and 11.8 g (0.085 mole) potassium carbonate in 175 mL of dimethylsulfoxide was heated at 70° C. for two days. The reaction mixture was cooled and filtered. The filtrate was diluted with water until a volume of one liter was obtained. This mixture was extracted with three 200 mL portions of diethyl ether. The combined ether extract was washed with water followed by an aqueous saturated sodium chloride solution. The washed extract was dried over anhydrous sodium sulfate and filtered. Evaporation of the filtrate under reduced pressure yielded 13.5 g 4-(4-chlorophenoxy)nitrobenzene (mp 67°-70° C.).

后处理

  1. temperatureThe reaction mixture was cooled
  2. filtrationfiltered
  3. additionThe filtrate was diluted with water until a volume of one liter
  4. customwas obtained
  5. extractionThis mixture was extracted with three 200 mL portions of diethyl ether
  6. extractionThe combined ether extract
  7. washwas washed with water
  8. extractionThe washed extract
  9. dry with materialwas dried over anhydrous sodium sulfate
  10. filtrationfiltered
  11. customEvaporation of the filtrate under reduced pressure

来源与证据

ORD记录
ord-c1a9a8715b9a4c9ebcfe2d77541c3e8e
来源数据集
uspto-grants-1988_08
专利号
US04767779

关联笔记

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