(5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮 → 3-(4-Azidophenyl)-1-(2-methoxyphenyl)prop-2-en-1-one

HRID 3765

反应方程式

HRID 3765 反应方程式
CO[CH2:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].[N:12]([C:15]1[CH:22]=[CH:21][C:18]([CH:19]=O)=[CH:17][CH:16]=1)=[N+:13]=[N-:14].[OH-:23].[Na+].[CH3:25]O>>[N:12]([C:15]1[CH:22]=[CH:21][C:18]([CH:19]=[CH:3][C:4]([C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:11]=2[O:23][CH3:25])=[O:5])=[CH:17][CH:16]=1)=[N+:13]=[N-:14]

参与物

5

反应物 4

HCID 887(5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮HCID 14798二甲基对苯二胺二盐酸HCID 776982-甲氧基苯乙酮HCID 90385对叠氮苯甲醛

产物 1

HCID 541487943-(4-Azidophenyl)-1-(2-methoxyphenyl)prop-2-en-1-one

反应条件

温度
25 °C

实验过程

In a 500-ml flask were placed 15 g of 2-methoxyacetophenone (made by Aldrich Co., 99% purity), 15 g of p-azidobenzaldehyde (manufactured by Kanto Chemical Co., Ltd.), 50 g of 10% aqueous solution of NaOH, and 50 g of methanol. The mixture was stirred in a yellow light at 25° C. for 24 hours. After completion of the reaction, the deposited crystals were filtered, washed with water, dried, and recrystallized from ethanol.

后处理

  1. customIn a 500-ml flask were placed
  2. customAfter completion of the reaction
  3. filtrationthe deposited crystals were filtered
  4. washwashed with water
  5. customdried
  6. customrecrystallized from ethanol

来源与证据

ORD记录
ord-844bfa4964764092a84084123ac463f1
来源数据集
uspto-grants-1988_02
专利号
US04722883

关联笔记

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