碘 → 3-羟基-2-碘-6-甲基吡啶

HRID 416559

反应方程式

HRID 416559 反应方程式
C(=O)([O-])[O-].[Na+].[Na+].[OH:7][C:8]1[CH:9]=[CH:10][C:11]([CH3:14])=[N:12][CH:13]=1.[I:15]I.[I-].[K+]>O>[I:15][C:13]1[C:8]([OH:7])=[CH:9][CH:10]=[C:11]([CH3:14])[N:12]=1

参与物

6

反应物 4

HCID 807碘HCID 4875碘化钾HCID 10340Carbonic acid sodium salt (1:2)HCID 142753-羟基-6-甲基吡啶

产物 1

HCID 899573-羟基-2-碘-6-甲基吡啶收率 43.9%

试剂、催化剂与溶剂 1

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂2 次

实验过程

Sodium carbonate (68.0 g) and water (810 mL) were added to 5-hydroxy-2-methylpyridine (1-014-01) (36.11 g), and the reaction mixture was stirred at room temperature, dissolved. To the reaction mixture was added dropwise a solution of iodine (117 g) and potassium iodide (117 g) in water (810 mL) for 35 min. The resulting pink-yellow crystal was filtered and dried under reduced pressure to give 2-iodo-3-hydroxy-6-methylpyridine (2-014-01) (34.1 g, 43.9%, m.p. 187-190° C.)

后处理

  1. dissolutiondissolved
  2. filtrationThe resulting pink-yellow crystal was filtered
  3. customdried under reduced pressure

来源与证据

ORD记录
ord-a2e97d959c4e4dd8b6b848baa7230577
来源数据集
uspto-grants-2012_01
专利号
US08088924B2

关联笔记

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