水合肼 → HCID 178470479，化合物
反应方程式
[CH2:1]([O:3][C:4]1[C:5](=O)[CH:6]([C:10](=O)[C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH2:7][CH2:8][CH:9]=1)[CH3:2].O.[NH2:19][NH2:20]>C(O)C>[CH2:1]([O:3][C:4]1[C:5]2[NH:20][N:19]=[C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:6]=2[CH2:7][CH2:8][CH:9]=1)[CH3:2]参与物
4
实验过程
1.2 g (5 mmol) of ethyl (3-ethoxy-2-oxocyclohex-3-en-1-yl)(oxo)acetate were dissolved in 20 mL of ethanol and 25 mL (5.2 mmol) of hydrazine hydrate 98% were added dropwise. The solution was stirred at room temperature for 5 hours, then heated at 60° C. for further 5 hours. The solvent was removed in vacuo and the residue taken up with diethyl ether and the resulting precipitate collected by filtration giving 0.8 g of the title compound, that was employed in the next step without any further purification.
后处理
- temperatureheated at 60° C. for further 5 hours
- customThe solvent was removed in vacuo
- filtrationthe resulting precipitate collected by filtration
来源与证据
- ORD记录
- ord-570cf764e18d4fcfa2f471c197fbdb8f
- 来源数据集
- uspto-grants-2013_09
- 专利号
- US08541429B2
反应笔记
加载中…