氢氧化钾 → 1-Chloro-4-(3-phenylpropyl)benzene

HRID 463513

反应方程式

HRID 463513 反应方程式
[C:1]1([CH2:7][CH2:8][C:9]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.NN.[OH-].[K+]>C(O)COCCO>[Cl:17][C:14]1[CH:13]=[CH:12][C:11]([CH2:9][CH2:8][CH2:7][C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[CH:16][CH:15]=1

参与物

5

反应物 3

HCID 14797氢氧化钾HCID 24654水合肼HCID 2473444'-氯-3-苯基苯丙酮

产物 1

HCID 133008571-Chloro-4-(3-phenylpropyl)benzene

试剂、催化剂与溶剂 1

HCID 8117二乙二醇溶剂

实验过程

p-chlorophenyl phenylethyl ketone (25 g) was refluxed with hydrazine hydrate (13 g) and potassium hydroxide (18 g) in Digol (diethylene glycol) for one hour. The mixture was then distilled until the solution temperature in the still reached 175°. The mixture was then refluxed for 3 hours, cooled, poured into water and extracted with petroleum ether (Bpt 40°-60°). Evaporation of the extracts gave 1-(4-chlorophenyl)-3-phenylpropane Bbt. 110°/10-3 mm.

后处理

  1. distillationThe mixture was then distilled until the solution temperature in the still reached 175°
  2. temperatureThe mixture was then refluxed for 3 hours
  3. temperaturecooled
  4. additionpoured into water
  5. extractionextracted with petroleum ether (Bpt 40°-60°)
  6. customEvaporation of the extracts

来源与证据

ORD记录
ord-3ea19a854acc474080cbdd3124680918
来源数据集
uspto-grants-1985_05
专利号
US04520007

关联笔记

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