4-溴苯酚 → 4-正辛氧基溴苯

HRID 525975

反应方程式

HRID 525975 反应方程式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.Br[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])=[CH:4][CH:3]=1

参与物

5

反应物 3

HCID 78084-溴苯酚HCID 81401-溴辛烷HCID 11430碳酸钾

产物 1

HCID 1452984-正辛氧基溴苯收率 87.4%

试剂、催化剂与溶剂 1

HCID 6228N,N-二甲基甲酰胺溶剂

实验过程

4-bromophenol (10.46 g, 60.5 mmol), 1-bromooctane (15.43 g, 79.9 mmol) and potassiumcarbonate (90 g, 0.65 mol) in N,N-dimethylformamide and was heated to 90° C. for 4 h and then the potassiumcarbonate was filtered off. The reaction mixture was quenched with water and extracted three times with ether. The ether was then washed three times with 1M hydrochloric acid (HCl), one time with water, evaporated, and purified by distillation to obtain 1-bromo-4-(octyloxy)benzene (15.1 g, 52.9 mmol) as a colourless oil.

后处理

  1. filtrationthe potassiumcarbonate was filtered off
  2. customThe reaction mixture was quenched with water
  3. extractionextracted three times with ether
  4. washThe ether was then washed three times with 1M hydrochloric acid (HCl), one time with water
  5. customevaporated
  6. distillationpurified by distillation

来源与证据

ORD记录
ord-cba53612026d4ccf92bb37ba1bbffbd2
来源数据集
uspto-grants-2016_05
专利号
US09343198B2

关联笔记

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