海萝胶 → 1-甲基-3-吲唑甲酸

HRID 5368

反应方程式

HRID 5368 反应方程式
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]([O:13]C)=[O:12])=[N:3]1.[OH-].[Na+].Cl>CO.O>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]([OH:13])=[O:12])=[N:3]1

参与物

6

反应物 3

HCID 313海萝胶HCID 14798二甲基对苯二胺二盐酸HCID 139005741-甲基-1H-吲唑-3-羧酸甲酯

产物 1

HCID 6891051-甲基-3-吲唑甲酸收率 92.1%

试剂、催化剂与溶剂 2

HCID 887(5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮溶剂HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂

实验过程

A solution of 1-methylindazole-3-carboxylic acid, methyl ester (1.00 g, 0.0053 mol) was stirred in a mixture of methanol (10 mL)/2N NaOH solution (120 mL) at reflux temperature for 2 hours. After cooling, the mixture was diluted with water (100 mL) and acidified with 6N HCl solution. The white solid that formed was collected by filtration and dried under ambient conditions for 6 days to give 0.86 g (92% yield) of the product; mp 215°-216° C.

后处理

  1. temperatureat reflux temperature for 2 hours
  2. temperatureAfter cooling
  3. customThe white solid that formed
  4. filtrationwas collected by filtration
  5. customdried under ambient conditions for 6 days

来源与证据

ORD记录
ord-76e193244c0648009545e2db9839eabd
来源数据集
uspto-grants-1993_09
专利号
US05244907

关联笔记

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