盐酸 → 4-氨基-5-氯-2-乙氧基苯甲酸

HRID 5877笔记

反应方程式

HRID 5877 反应方程式
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([NH2:12])[C:9]([Cl:13])=[CH:8][C:4]=1[C:5]([OH:7])=[O:6].Cl.[CH3:15]O>>[CH3:1][O:2][C:3]1[CH:11]=[C:10]([NH2:12])[C:9]([Cl:13])=[CH:8][C:4]=1[C:5]([O:7][CH3:15])=[O:6]

参与物

4

反应物 3

HCID 313盐酸HCID 887(5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮HCID 816264-氨基-5-氯-2-甲氧基苯甲酸

产物 1

HCID 7004934-氨基-5-氯-2-乙氧基苯甲酸

实验过程

To a solution of 50g of 2-methoxy-4-amino-5-chlorobenzoic acid in 500 ml of methanol is added HCl gas until all the material dissolves. Stirring is continued overnight, the solvent removed, ether added, filtered, dried over magnesium sulfate and evaporated to dryness to obtain methyl 2-methoxy-4-amino-5-chlorobenzoate which is used directly in the next step.

后处理

  1. dissolutiondissolves
  2. customthe solvent removed
  3. additionether added
  4. filtrationfiltered
  5. dry with materialdried over magnesium sulfate
  6. customevaporated to dryness

来源与证据

ORD记录
ord-1eb26c95049e45f5a0d34f4298931c2b
来源数据集
uspto-grants-1993_09
专利号
US05246942

反应笔记

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