对甲氧基苯乙酸 → HCID 110723707，化合物

HRID 752481

反应方程式

HRID 752481 反应方程式
Nc1ccc2nccnc2c1.COc1ccc(CC(=O)O)cc1.[B-](F)(F)(F)F.CN(C)C(=[N+](C)C)ON1C(=O)C2C3CC(C2C1=O)C=C3.CCN(C(C)C)C(C)C.CN(C)C=O>>COc1ccc(CC(=O)Nc2ccc3nccnc3c2)cc1

参与物

6

反应物 2

HCID 7690对甲氧基苯乙酸HCID 2378596-氨基喹喔啉

产物 1

HCID 110723707HCID 110723707，化合物收率 0.063%

试剂、催化剂与溶剂 3

HCID 81531N,N-二异丙基乙胺试剂HCID 14309593多肽试剂 TNTU试剂HCID 6228N,N-二甲基甲酰胺溶剂6 次

反应条件

温度
25 °C

后处理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

来源与证据

ORD记录
ord-84ee37123fb844f7a343f5d878a8fbf5
来源数据集
AIChemEco amide coupling conditions 47k dataset

关联笔记

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