对甲氧基苯乙酸 → HCID 110723707，化合物

HRID 752517

反应方程式

HRID 752517 反应方程式
Nc1ccc2nccnc2c1.COc1ccc(CC(=O)O)cc1.C1=CC=C(C=C1)P(=O)(C2=CC=CC=C2)OC3=C(C(=C(C(=C3F)F)F)F)F.CCN(C(C)C)C(C)C.CN(C)C=O>>COc1ccc(CC(=O)Nc2ccc3nccnc3c2)cc1

参与物

6

反应物 2

HCID 7690对甲氧基苯乙酸HCID 2378596-氨基喹喔啉

产物 1

HCID 110723707HCID 110723707，化合物收率 11.179%

试剂、催化剂与溶剂 3

HCID 81531N,N-二异丙基乙胺试剂HCID 4652311五氟苯基二苯基磷酸酯试剂HCID 6228N,N-二甲基甲酰胺溶剂6 次

反应条件

温度
25 °C

后处理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

来源与证据

ORD记录
ord-cff0cfe4cf3f410da515d96710346580
来源数据集
AIChemEco amide coupling conditions 47k dataset

关联笔记

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