氯化苄 → Methyl 2,3-bis(benzyloxy)benzoate

HRID 76088笔记

反应方程式

HRID 76088 反应方程式
[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([OH:10])[C:5]=1[OH:11].[CH2:13](Cl)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:5]=1[O:11][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

参与物

3

反应物 2

HCID 7503氯化苄HCID 754842,3-二羟基苯甲酸甲酯

产物 1

HCID 10665397Methyl 2,3-bis(benzyloxy)benzoate

实验过程

In one embodiment, the compounds can be prepared as shown in Scheme II. A dihydroxy benzoic acid methyl ester is reacted with benzyl chloride, to produce a Bis-benzyloxy benzoic acid methyl ester (1). The Bis-benzyloxy benzoic acid methyl ester can then be heated with LiOH to give a Bis-benzyloxy benzoic acid (2). The Bis-benzyloxy benzoic acid (2) is then reacted with an aminophenyl to produce a phenyl-benzamide (3). The phenyl-benzamide (3) is then reacted with hydrazine to give a triazol (4). The hydroxy groups can then be unprotected in the presence of palladium on charcoal to give the final product.

后处理

  1. customIn one embodiment, the compounds can be prepared

来源与证据

ORD记录
ord-ebfc6169a3ab4ce89cf4bf4ea3f92fa0
来源数据集
uspto-grants-2014_09
专利号
US08835464B2

反应笔记

加载中…