氯化亚砜 → HCID 66937557，化合物

HRID 79370

反应方程式

HRID 79370 反应方程式
[CH3:1][N:2]1[C:6]([CH3:7])=[CH:5][C:4]([CH2:8]O)=[N:3]1.S(Cl)([Cl:12])=O>C(Cl)Cl>[ClH:12].[Cl:12][CH2:8][C:4]1[CH:5]=[C:6]([CH3:7])[N:2]([CH3:1])[N:3]=1

参与物

4

反应物 2

HCID 24386氯化亚砜HCID 27763661,5-二甲基-1H-吡唑-3-甲醇

产物 1

HCID 66937557HCID 66937557，化合物收率 101.8%

试剂、催化剂与溶剂 1

HCID 6344二氯甲烷溶剂

实验过程

To (1,5-dimethyl-1H-pyrazol-3-yl)methanol (5.01 g, 39.71 mmol) in DCM (80 mL) at 0° C. was cautiously added thionyl chloride (25 mL, 343.6 mmol). The cold bath was removed and the reaction mixture was stirred at ambient temperature for 3 hours. The reaction mixture was concentrated under reduced pressure to give crude product (7.32 g).

后处理

  1. customat 0° C.
  2. customThe cold bath was removed
  3. concentrationThe reaction mixture was concentrated under reduced pressure

来源与证据

ORD记录
ord-a0e28097d0434a88bd9c842f43cfe4a0
来源数据集
uspto-grants-2014_09
专利号
US08841455B2

关联笔记

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