丙酮酸 → 2-(2,3,4-Trifluoroanilino)propionic acid

HRID 8440

反应方程式

HRID 8440 反应方程式
[F:1][C:2]1[C:7]([F:8])=[C:6]([F:9])[CH:5]=[CH:4][C:3]=1[N+:10]([O-])=O.[C:13]([OH:18])(=[O:17])[C:14]([CH3:16])=O>CO.[Pd]>[F:1][C:2]1[C:7]([F:8])=[C:6]([F:9])[CH:5]=[CH:4][C:3]=1[NH:10][CH:14]([CH3:16])[C:13]([OH:18])=[O:17]

参与物

5

反应物 2

HCID 1060丙酮酸HCID 698712,3,4-三氟硝基苯

产物 1

HCID 220158662-(2,3,4-Trifluoroanilino)propionic acid收率 96%

试剂、催化剂与溶剂 2

HCID 23938钯催化剂HCID 887(5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮溶剂

反应条件

温度
40 °C

实验过程

2,3,4-Trifluoronitrobenzene (1.01 g) and pyruvic acid (0.75 g) were dissolved in methanol (8 ml). After adding 5% Pd—C (0.11 g), the mixture was stirred at 40° C. under a hydrogen gas pressure of 4.9 MPa (converted from 50 kgf/cm2) for 5 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (1.20 g) was obtained as colorless crystals. Various spectral data of this product was identical with those of a specimen synthesized separately.

后处理

  1. filtrationAfter filtering off Pd—C
  2. concentrationthe obtained filtrate was concentrated under reduced pressure

来源与证据

ORD记录
ord-4fb047e8329c4843bff603683d0831d1
来源数据集
uspto-grants-2006_08
专利号
US07087778B2

关联笔记

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