乙二醇二甲醚 → 4-氮杂苯并咪唑

HRID 849478

反应方程式

HRID 849478 反应方程式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.C(COC)OC.C(=O)([O-])[O-].[K+].[K+].[CH2:20]([N:22](CC)CC)C>>[NH:22]1[C:7]2[CH:6]=[CH:5][CH:4]=[N:3][C:2]=2[N:1]=[CH:20]1

参与物

5

反应物 4

HCID 8071乙二醇二甲醚HCID 8471三乙胺HCID 104392-氨基吡啶2 次HCID 11430碳酸钾

产物 1

HCID 675044-氮杂苯并咪唑

实验过程

Imidazopyridine salt E-3 is prepared from aminopyridine E-1 (also D-1) (refer to Chart D) (commercial source) or the amino pyridine A-2 (refer to Chart A) and dihaloacetone E-2 (Aldrich) either by a two-step procedure whereby E-1 and E-2 are stirred in a solvent such as dimethoxyethane with or without the addition of a base such as triethylamine or potassium carbonate to give imidazopyridine salt E-3. If dimethoxyethane alone is used as solvent, it is then replaced with alcoholic solvent and E-3 is heated until no additional E-4 is formed.

来源与证据

ORD记录
ord-9a8146e705ca467fa81e6b7e20e0288b
来源数据集
uspto-grants-2000_01
专利号
US06013654

关联笔记

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