三乙胺 → HCID 67386992，化合物

HRID 908321笔记

反应方程式

HRID 908321 反应方程式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:13]2[CH:18]=[CH:17][C:16]([N:19]3[C:23](=[O:24])[CH2:22][CH:21]([C:25]([O:27]C)=[O:26])[CH2:20]3)=[CH:15][CH:14]=2)=[C:7]2[C:12]=1[CH:11]=[N:10][CH:9]=[CH:8]2.[OH-].[Na+].CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CCN(CC)CC>O1CCOCC1>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:13]2[CH:14]=[CH:15][C:16]([N:19]3[C:23](=[O:24])[CH2:22][CH:21]([C:25]([OH:27])=[O:26])[CH2:20]3)=[CH:17][CH:18]=2)=[C:7]2[C:12]=1[CH:11]=[N:10][CH:9]=[CH:8]2

参与物

6

反应物 4

HCID 8471三乙胺HCID 14798氢氧化钠HCID 2733084Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 58828844HCID 58828844，化合物

产物 1

HCID 67386992HCID 67386992，化合物

试剂、催化剂与溶剂 1

HCID 312751,4-二氧六环溶剂

反应条件

温度
80 °C

实验过程

A mixture of methyl 1-(4-(8-methoxyisoquinolin-5-yl)phenyl)-5-oxopyrrolidine-3-carboxylate (220 mg, 0.58 mmol) in dioxane (2 mL) was treated with NaOH (1N, 1 mL). The mixture was heated to 80° C. for 17 h and the solvents were evaporated to dryness. MS (ESI pos. ion) m/z: 363 (M+H). The acid was dissolved in DMF (2 mL) and was treated with HBTU (450 mg, 1.25 mmol) and Et3N (1 mL). The solution was divided into two equal portions and was used directly.

后处理

  1. customthe solvents were evaporated to dryness
  2. dissolutionThe acid was dissolved in DMF (2 mL)

来源与证据

ORD记录
ord-991abe7f7c2a4acdaad03154b2d636fb
来源数据集
uspto-grants-2011_09
专利号
US08017601B2

反应笔记

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