Government regulation → 1-(1-乙酰哌啶-4-基)-2-溴乙-1-酮

HRID 911908笔记

反应方程式

HRID 911908 反应方程式
[N:1]1([C:10](=[O:12])[CH3:11])[CH2:6][CH2:5][CH:4]([C:7](=[O:9])[CH3:8])[CH2:3][CH2:2]1.[Br:13]Br>CO>[C:10]([N:1]1[CH2:6][CH2:5][CH:4]([C:7](=[O:9])[CH2:8][Br:13])[CH2:3][CH2:2]1)(=[O:12])[CH3:11]

参与物

4

反应物 2

HCID 24408Government regulationHCID 27772501,4-二乙酰基哌啶

产物 1

HCID 772303261-(1-乙酰哌啶-4-基)-2-溴乙-1-酮

试剂、催化剂与溶剂 1

HCID 887Methanol溶剂

实验过程

1,1′-(Piperidine-1,4-diyl)diethanone (38.0 g, 225 mmol) was dissolved in methanol (700 mL) and bromine (12.1 mL, 236 mmol) was added. After agitating for 3 hours the solvent was removed. The resulting solid was washed with ethyl acetate, then distributed between ethyl acetate and sodium carbonate. The organic phase was separated, washed with brine, dried and evaporated to give the title compound.

后处理

  1. customwas removed
  2. washThe resulting solid was washed with ethyl acetate
  3. customThe organic phase was separated
  4. washwashed with brine
  5. customdried
  6. customevaporated

来源与证据

ORD记录
ord-ec871ec3268444dd86aae805128356d6
来源数据集
uspto-grants-2011_09
专利号
US08022223B2

反应笔记

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