4-溴苯酚 → 1-Bromo-4-{[(3S)-3,7-dimethyloct-6-en-1-yl]oxy}benzene
反应方程式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[CH2:9](Br)[CH2:10][C@H:11]([CH2:13][CH2:14][CH:15]=[C:16]([CH3:18])[CH3:17])[CH3:12].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:9][CH2:10][C@@H:11]([CH3:12])[CH2:13][CH2:14][CH:15]=[C:16]([CH3:18])[CH3:17])=[CH:4][CH:3]=1参与物
5
实验过程
A mixture of 4-bromophenol (34.6 g, 0.20 mol), (S)-(+)-citronellyl bromide (50 g, 0.023 mol) and potassium carbonate (45 g, 0.33 mol) in butanone (500 cm3) was heated under reflux overnight. The cooled reaction mixture was filtered and the filtrate concentrated under reduced pressure. The crude product was purified by fractional distillation to yield 42.3 g (68.2%) of the desired product.
后处理
- temperaturewas heated
- temperatureunder reflux overnight
- customThe cooled reaction mixture
- filtrationwas filtered
- concentrationthe filtrate concentrated under reduced pressure
- distillationThe crude product was purified by fractional distillation
来源与证据
- ORD记录
- ord-10e3b97bc0a44d04b2c21c83c09c4f3a
- 来源数据集
- uspto-grants-2007_09
- 专利号
- US07265163B2
反应笔记
加载中…