(5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮 → Dimethyl 2-formylcyclopropane-1,1-dicarboxylate

HRID 971925笔记

反应方程式

HRID 971925 反应方程式
[CH:1]([CH:3]1[CH2:5][C:4]1([C:11]([O:13][CH2:14]C)=[O:12])[C:6]([O:8][CH2:9]C)=[O:7])=[O:2].C(C=C)=O.COC(=O)C(Br)C(OC)=O.CO>C(O)C>[CH:1]([CH:3]1[CH2:5][C:4]1([C:6]([O:8][CH3:9])=[O:7])[C:11]([O:13][CH3:14])=[O:12])=[O:2]

参与物

6

反应物 4

HCID 887(5BETA,17BETA)-17-羟基-17-(甲基-D3)-2'H-雄甾-2-烯并[3,2-C]吡唑-5'(1'H)-酮HCID 7847丙烯醛HCID 70087溴丙二酸二甲酯HCID 5337391,1-Diethyl 2-formylcyclopropane-1,1-dicarboxylate

产物 1

HCID 10899359Dimethyl 2-formylcyclopropane-1,1-dicarboxylate

试剂、催化剂与溶剂 1

HCID 702乙醇溶剂

实验过程

By following the procedure of D. T. Warner, cited above, used for preparing diethyl 2-formylcyclopropane-1,1-dicarboxylate from acrolein but using equivalent amount of dimethylbromomalonate and methanol instead of diethylbromomalonate and ethanol, respectively, the title compound, nmr (CDCl3) δ 1.98 (m,2H), 2.80 (m,1H), 3.79 (s,6H), 8.82 (d, J=4 cps, 1H), is obtained.

来源与证据

ORD记录
ord-8da759ba1a644180a25dba7ea81a46ac
来源数据集
uspto-grants-1979_07
专利号
US04161608

反应笔记

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