LY3295668 → HCID 20309603，化合物

HRID 972796笔记

反应方程式

HRID 972796 反应方程式
[C:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([O:19][CH2:20][CH:21]2[O:23][CH2:22]2)=[C:9]([CH:18]=1)[C:10]([CH2:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])=[O:11])(=[O:3])[CH3:2].[C:24]([NH2:28])([CH3:27])([CH3:26])[CH3:25]>CO>[C:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([O:19][CH2:20][CH:21]([OH:23])[CH2:22][NH:28][C:24]([CH3:27])([CH3:26])[CH3:25])=[C:9]([CH:18]=1)[C:10]([CH2:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])=[O:11])(=[O:3])[CH3:2]

参与物

4

反应物 2

HCID 6385LY3295668HCID 20309567HCID 20309567，化合物

产物 1

HCID 20309603HCID 20309603，化合物收率 33%

试剂、催化剂与溶剂 1

HCID 887Methanol溶剂

实验过程

A solution of methyl 3-[5-acetamido-2-(2,3-epoxypropoxy)benzoyl]propionate (0.52 g, 0.0016 mole), t-butylamine (20 ml) and methanol (10 ml) was heated under reflux for 16 hours. Evaporation of the reaction mixture left an oil which was dissolved in ethanol and treated with ether to give crystalline methyl 3-[5-acetamido-2-(3-t-butylamino-2-hydroxypropoxy)benzoyl]propionate (0.21 g, 33%; m.p. 127°-128°).

后处理

  1. temperatureunder reflux for 16 hours
  2. customEvaporation of the reaction mixture
  3. waitleft an oil which
  4. dissolutionwas dissolved in ethanol
  5. additiontreated with ether

来源与证据

ORD记录
ord-2454a1286b5940128dce8d8198923ab1
来源数据集
uspto-grants-1977_10
专利号
US04053601

反应笔记

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