Sch 28080
Grundinformationen
- CAS
76081-98-6- Standard-SMILES
Cc1nc2c(OCc3ccccc3)cccn2c1CC#N- InChIKey
PYKJFEPAUKAXNN-UHFFFAOYSA-N- Summenformel
- C17H15N3O
- Durchschnittliche Molmasse
- 277,32 g/mol
- Monoisotopische Masse
- 277,12151211
Namen und Bezeichner
- Bevorzugter Name
- Sch 28080
- IUPAC
- 2-(2-methyl-8-phenylmethoxyimidazo[1,2-a]pyridin-3-yl)acetonitrile
- Englischer Name
- 2-Methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile
- Summenformel
- C17H15N3O
- Molmasse
- 277.32
Namen und Synonyme
76081-98-6Sch 28080Sch-28080SCH28080Schering compound 28080S28080Imidazo(1,2-a)pyridine-3-acetonitrile, 2-methyl-8-(phenylmethoxy)-00427X161IDTXSID10226971RefChem:181724DTXCID401494622-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile
Weitere Namen anzeigen
SCH-28080,SCH28080SCH28080, 10 mM in DMSOimidazo-(1-2-a)pyrine-3-acetonitrile2-Methyl-8-(phenylmethoxy)imidazo-(1-2-A)pyrine-3-acetonitrile
2-(8-(benzyloxy)-2-methylimidazo[1,2-a]pyridin-3-yl)acetonitrileLopac-S-4443CHEMBL475292-[8-(benzyloxy)-2-methylimidazo[1,2-a]pyridin-3-yl]acetonitrileLP00439SDCCGSBI-0050424.P002NCGC00015953-01NCGC00015953-03
Datenbank-Bezeichner
- CAS
76081-98-6- PubChem CID
- 108137
- DTXSID
DTXSID10226971- ChEMBL
CHEMBL47529- ChEBI
CHEBI:92978- UNII
- 00427X161I
- Nikkaji
- J23.600D
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 3,3
- Polarare Oberfläche (TPSA)
- 50,3 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 3
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 21
- Formalladung
- 0
- Komplexität
- 385
Physikochemische Eigenschaften
- Dichte
- 1.16 · 1.16±0.1 g/cm3(Predicted)
- storage temp.
- -20 °C · -20°C
- Löslichkeit
- 10 mg/mL, · DMSO: >10 mg/mL, soluble
- Aggregatzustand
- solid
- pka
- 5.85 · 5.85±0.10(Predicted)
- Farbe
- white to light tan
- InChI
- 1S/C17H15N3O/c1-13-15(9-10-18)20-11-5-8-16(17(20)19-13)21-12-14-6-3-2-4-7-14/h2-8,11H,9,12H2,1H3
- InChIKey
- PYKJFEPAUKAXNN-UHFFFAOYSA-N
- SMILES
- Cc1nc2c(OCc3ccccc3)cccn2c1CC#N
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- safety_code
- 22-24/25
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Anwendungen
BeschreibungSCH 28080 is a reversible K+-competitive inhibitor of H+/K+-ATPases that is best known for its ability to block acid secretion through its action against the gastric H+/K+-ATPase (IC50 = 1.3 μM). It is effective against gastric H+/K+-ATPases from a variety of species and can inhibit colonic H+/K+-ATPases, but this activity appears to be species-dependent. SCH 28080 is also used to investigate the role of H+/K+-ATPases in non-mammalian organisms and to distinguish the actions of H+/K+-ATPases from other ATP-dependent transporters.
VerwendenSCH 28080 is a potent inhibitor of H+,K+-ATPase.
Anbieter25 Anbieter
陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
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