N-Iodosuccinimide → 2-n-Butyl-5-hydroxymethyl-4-iodoimidazole

HRID 2345

Reaktionsgleichung

Reaktionsgleichung von HRID 2345
[I:1]N1C(=O)CCC1=O.[CH2:9]([C:13]1[NH:14][CH:15]=[C:16]([CH2:18][OH:19])[N:17]=1)[CH2:10][CH2:11][CH3:12]>C(O)C.O>[CH2:9]([C:13]1[NH:17][C:16]([CH2:18][OH:19])=[C:15]([I:1])[N:14]=1)[CH2:10][CH2:11][CH3:12]

Komponenten

5

Edukt 2

HCID 120273N-IodosuccinimideHCID 178418407HCID 178418407, Verbindung

Produkt 1

HCID 148985472-n-Butyl-5-hydroxymethyl-4-iodoimidazoleAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

N-iodosuccinimide (148.75 g, 0.661 mol) was added to a stirred solution of 2-n-butyl-4-hydroxymethylimidazole (100.78 g, 0.652 mol) in 500 ml of absolute ethanol. After 20 minutes the solution was heated to 40°-45° C. for 45 minutes, diluted with 2.5 L of water, and chilled. The crystalline product which formed was collected by filtration, washed with water, and dried to give 1.74.5 g (95%) of crystals; mp 166°-166.5° C.

Aufarbeitung

  1. temperatureAfter 20 minutes the solution was heated to 40°-45° C. for 45 minutes
  2. temperaturechilled
  3. customThe crystalline product which formed
  4. filtrationwas collected by filtration
  5. washwashed with water
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-132a212c419b44f6b52e3b5ef79af5b4
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05728842

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