Succinimidyl 4-(N-maleimidomethyl)cyclohexanecarboxylate

HCID 125175CAS 64987-85-5
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Grundinformationen

Standard-SMILES
O=C(ON1C(=O)CCC1=O)C1CCC(CN2C(=O)C=CC2=O)CC1
InChIKey
JJAHTWIKCUJRDK-UHFFFAOYSA-N
Summenformel
C16H18N2O6
Durchschnittliche Molmasse
334,32 g/mol
Monoisotopische Masse
334,1164863

Überblick

Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate is an N-hydroxysuccinimide ester derived from 4-(N-maleimidomethyl)cyclohexane-1-carboxylic acid. It is a N-hydroxysuccinimide ester and a member of maleimides.

Namen und Bezeichner

Bevorzugter Name
Succinimidyl 4-(N-maleimidomethyl)cyclohexanecarboxylate
IUPAC
(2,5-dioxopyrrolidin-1-yl) 4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexane-1-carboxylate
Englischer Name
SMCC crosslinker
Summenformel
C16H18N2O6
Molmasse
334.32

Namen und Synonyme

64987-85-5N-Smc-carboxylateB357P1G1IFN-(4-Carboxycyclohexylmethyl)maleimide N-hydroxysuccinimide esterN-Hydroxysuccinimidyl 4-(N-maleimidomethylcyclohexane)-1-carboxylateDTXSID30215307N-Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylic acid1H-Pyrrole-2,5-dione, 1-((4-(((2,5-dioxo-1-pyrrolidinyl)oxy)carbonyl)cyclohexyl)methyl)-Succinimidyl 4-(N-maleimidomethyl)cyclohexanecarboxylateSMCC compoundRefChem:394650DTXCID90137798
Weitere Namen anzeigen
N-Succinimidyl 4-(maleimidomethyl)cyclohexanecarboxylate, SMCCNSC 344483LKAR3-RM1SMCC，98%SMCC[573114]25MG/100MG/10G
SMCC71875-81-52,5-Dioxopyrrolidin-1-yl 4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexanecarboxylateTRANS-4-(MALEIMIDOMETHYL)CYCLOHEXANECARBOXYLIC ACID-NHSN-Succinimidyl 4-(Maleimidomethyl)cyclohexane-1-carboxylateSMCC crosslinkerN-Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylatetrans-2,5-Dioxopyrrolidin-1-yl 4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexanecarboxylate

Datenbank-Bezeichner

CAS
64987-85-5
PubChem CID
125175
DTXSID
DTXSID30215307
ChEBI
CHEBI:63174
UNII
B357P1G1IF
EC Number
613-734-7、694-914-2
Nikkaji
J416.284F、J555.938C

Eigenschaften

Berechnete Struktureigenschaften

XLogP
-0,1
Polarare Oberfläche (TPSA)
101 Ų
H-Brücken-Donoren
0
H-Brücken-Akzeptoren
6
Frei drehbare Bindungen
5
Schwere Atome
24

Physikochemische Eigenschaften

Schmelzpunkt
180 · 180-182 °C (lit.)
Siedepunkt
501.7 · 501.7±42.0 °C(Predicted)
Dichte
1.42 · 1.42±0.1 g/cm3(Predicted)
storage temp.
-20 °C · -20°C
Löslichkeit
50 mg/mL · chloroform: 50 mg/mL
Aggregatzustand
powder

Sicherheit und Regulatorisches

GHS-Klassifizierung

GHS Classification · 6 Einträge

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 82 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

Gefahrenhinweise

Hazard Classes and Categories · 2 Einträge

Skin Irrit. 2 (100%)

Skin Irrit. 2 (100%)

Sicherheitsdaten

F
10-21
wgk
3
hs_code
29280000
risk_code
36/37/38
hazard_code
Xi
safety_code
26-36-60-37

Chemie und Industrie

Anwendungen · 2 Einträge

BeschreibungSMCC crosslinker is a hetero-bifunctional crosslinker that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. SMCC crosslinker must be dissolved in an organic solvent, such as DMSO or DMF, and then can be added to an aqueous crosslinking reaction. SMCC crosslinking reagent is permeable across the lipid bilayer of the cell membrane and can be used to crosslink intracellular proteins and peptides.

VerwendenA sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent. It conjugates anti-digoxin F(abTaIII)2 fragments to l-B-galactosidase. Conjugates hIgG to alkaline phosphatase.Spacer Arm: 11.6 Angstroms.

Vor- und nachgelagerte Produkte

Nachgelagerte Produkte

Anbieter50 Anbieter

北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
T&W GROUP021-61551611 13296011611 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
浙江珲达生物科技有限公司0571-89903022 18679456698 · [email protected]

Ergänzende Hinweise

DefinitionChEBI: Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate is an N-hydroxysuccinimide ester derived from 4-(N-maleimidomethyl)cyclohexane-1-carboxylic acid. It is a member of maleimides and a N-hydroxysuccinimide ester.

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